DESTAF: A database of text-mined associations for reproductive toxins potentially affecting human fertility

The Dragon Exploration System for Toxicants and Fertility (DESTAF) is a publicly available resource which enables researchers to efficiently explore both known and potentially novel information and associations in the field of reproductive toxicology. To create DESTAF we used data from the literature (including over 10 500 PubMed abstracts), several publicly available biomedical repositories, and specialized, curated dictionaries. DESTAF has an interface designed to facilitate rapid assessment of the key associations between relevant concepts, allowing for a more in-depth exploration of information based on different gene/protein-, enzyme/metabolite-, toxin/chemical-, disease- or anatomically centric perspectives. As a special feature, DESTAF allows for the creation and initial testing of potentially new association hypotheses that suggest links between biological entities identified through the database.DESTAF, along with a PDF manual, can be found at http://cbrc.kaust.edu.sa/destaf. It is free to academic and non-commercial users and will be updated quarterly.

► Associations mined from published literature using specialized, curated dictionaries.
► Integration with other information sources including Reactome, EntrezGene and UniProt.
► Exploration of mined associations from multiple dictionary-centric perspectives.
► Hypothesis generation to test for potentially new links between mined entities.
► Publicly available and updated quarterly.