کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2594400 | 1132267 | 2008 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice Effects of tartrazine on exploratory behavior in a three-generation toxicity study in mice](/preview/png/2594400.png)
Tartrazine was given to mice in the diet at levels of 0 (control), 0.05%, 0.15%, and 0.45% from 5 weeks of age of the F0 generation to 9 weeks of age of the F2 generation, and selected reproductive and neurobehavioral parameters were measured. In the F1 generation, the development of swimming direction at postnatal day (PND) 7 was accelerated significantly in male offspring in a dose-related manner. Surface righting at PND 7 was affected significantly in female offspring in dose-related manner. Several variables in exploratory behavior showed significant tendencies to be affected in the treatment groups in male offspring at 3 weeks of age. In the F2 generation, the development of swimming direction at PND 7 was accelerated significantly in the high-dosed group in male offspring. Time taken of olfactory orientation at PND 14 was accelerated significantly in male offspring in a dose-related manner. Several variables in exploratory behavior showed significant tendencies to be affected in the treatment groups in male offspring at 3 weeks of age, and in males at 8 weeks of age. The dose levels of tartrazine in the present study produced a few adverse effects on neurobehavioral parameters throughout generations in mice.
Journal: Reproductive Toxicology - Volume 26, Issue 2, October 2008, Pages 156–163