کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2594526 1132271 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The effects of prenatal exposure to atrazine on pubertal and postnatal reproductive indices in the female rat
چکیده انگلیسی

Atrazine (ATR) is an herbicide that exerts negative reproductive effects. We examined the effects of vehicle or ATR (1, 5, 20 and 100 mg/kg-d), administered to Sprague-Dawley rats on gestational days 14–21, once daily or divided into two doses per day, on female offspring reproductive indices. Offspring body weights at birth were reduced and mortality increased in the 100 mg/kg-d group shortly after birth; by PND 21 there were no significant effects. Vaginal opening was delayed in this group, indicating delayed puberty. No significant differences in mammary gland development were apparent at PND 45, or estrous cyclicity through PND 272. There were no differences between dosing regimens. Lower ATR doses (0–20 mg/kg-d) showed few effects in females prenatally exposed to ATR, while the high dose (100 mg/kg-d) reduced offspring body weight and delayed vaginal opening. Nonetheless, it is unlikely that environmental exposure comparable to the high dose would be encountered.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 32, Issue 1, July 2011, Pages 43–51
نویسندگان
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