کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2594626 1132275 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cadmium-induced gene expression changes in the mouse embryo, and the influence of pretreatment with zinc
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Cadmium-induced gene expression changes in the mouse embryo, and the influence of pretreatment with zinc
چکیده انگلیسی

Cadmium (Cd) administered to female C57BL/6 mice on gestation day 8 induces a high incidence of anterior neural tube defects (exencephaly). This adverse effect can be attenuated by maternal pretreatment with zinc (Zn). In this study we used replicated microarray analysis and real-time PCR to investigate gene expression changes induced in the embryo 5 and 10 h after maternal Cd exposure in the absence or presence of Zn pretreatment. We report nine genes with a transcriptional response induced by Cd, none of which was influenced by Zn pretreatment, and two genes induced only by combined maternal Cd exposure and Zn pretreatment. We discuss the results in relation to the possibility that Cd is largely excluded from the embryo, that the teratogenic effects of Cd may be secondary to toxicity in extraembryonic tissues, and that the primary protective role of Zn may not be to reverse Cd-induced transcription in the embryo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 22, Issue 4, November 2006, Pages 636–646
نویسندگان
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