کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2594735 1132277 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Environmental toxicants and the developing immune system: A missing link in the global battle against infectious disease?
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Environmental toxicants and the developing immune system: A missing link in the global battle against infectious disease?
چکیده انگلیسی

There is now compelling evidence that developmental exposure to chemicals from our environment contributes to disease later in life, with animal models supporting this concept in reproductive, metabolic, and neurodegenerative diseases. In contrast, data regarding how developmental exposures impact the susceptibility of the immune system to functional alterations later in life are surprisingly scant. Given that the immune system forms an integrated network that detects and destroys invading pathogens and cancer cells, it provides the body's first line of defense. Thus, the consequences of early life exposures that reduce immune function are profound. This review summarizes available data for pollutants such as cigarette smoke and dioxin-like compounds, which consistently support the idea that developmental exposures critically impact the immune system. These findings suggest that exposure to common chemicals from our daily environment represent overlooked contributors to the fact that infectious diseases remain among the top five causes of death worldwide.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 31, Issue 3, April 2011, Pages 327–336
نویسندگان
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