کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595130 1562187 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Induction of meiotic micronuclei in spermatocytes in vivo by aflatoxin B1: Light and transmission electron microscopic study in Swiss mouse
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Induction of meiotic micronuclei in spermatocytes in vivo by aflatoxin B1: Light and transmission electron microscopic study in Swiss mouse
چکیده انگلیسی

Dietary aflatoxins produce a disease state known as aflatoxicosis, and disruption of spermatogenesis is one of its serious consequences. Towards finding the cellular targets in spermatogenic compartment for aflatoxin toxicity, aflatoxin B1 (AFB1) was administered to 90-day-old Swiss mouse through i.p. route at a daily dose of 20 μg per kg body weight for 7, 15, 35 and 45 days. The testis and epididymis were subjected to light- as well as transmission electron microscopic analysis. One of the newer observations was occurrence of meiotic micronucleate giant spermatocytes in seminiferous epithelium and epididymal lumen. The origin of these cells could be traced to imminent disruption of spindle apparatus during meiotic division of spermatocytes, resulting in lagging of chromosome bivalents or replicated univalents. Such chromosomes appeared to undergo condensation and become micronuclei. Thus, this study reports that aflatoxin exposure would result in generation of meiotic micronucleate giant spermatocytes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 26, Issues 3–4, November–December 2008, Pages 303–309
نویسندگان
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