کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595221 1562188 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Down syndrome time-clustering in January 1987 in Belarus: Link with the Chernobyl accident?
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Down syndrome time-clustering in January 1987 in Belarus: Link with the Chernobyl accident?
چکیده انگلیسی

The Chernobyl accident (April 26, 1986) exposed a large part of the Belarus population to ionizing radiation. We analyzed the time trends of Down syndrome (DS) in Belarus to evaluate whether either brief exposure at high dose rates during the plume passage or continuous exposure at low doses and dose rates of the residents of contaminated areas had any detectable impact on DS prevalence at birth. DS data came from the Belarus National Registry of Congenital Malformations (1981–2001). We observed a significant peak of DS in January 1987 (26 cases observed and 9.84 expected; observed/expected ratio = 2.64; 95% CI = 1.72–3.76), but found no positive long-term time trends in contaminated or control areas. The time occurrence of the January peak, high dose rates during the plume passage and experimental data showing a radiosensitive phase of oogenesis around conception time in mammals suggest that the January peak may be linked to the Chernobyl plume.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 24, Issues 3–4, November–December 2007, Pages 289–295
نویسندگان
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