کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595234 1562188 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Chromium induced testicular impairment in relation to adrenocortical activities in adult albino rats
چکیده انگلیسی

The present study investigates the testicular and adrenocortical activities under different doses and durations of chromium (Cr) exposure and their interactions. Mature male Sprague Dawley rats were injected daily with three different doses (0.2, 0.4, and 0.6 mg/kg bw) of Cr salt (K2Cr2O7) intraperitonealy for 13 and 26 days, respectively. The medium (0.4 mg/kg bw/day) and higher dose (0.6 mg/kg bw/day) of Cr significantly (p < 0.05) decrease accessory sex organs weight, testicular Δ53β-hydroxysteroid dehydrogenase (HSD) and 17β-HSD activities, epididymal sperm count, effective spermatid degeneration, serum testosterone, LH level, testicular catalase and superoxide dismutase (SOD) activities while testicular lipid peroxidation, serum FSH, corticosterone level, adrenal weight and adrenal Δ53β-HSD activity increased significantly than that of control and lower dose (0.2 mg/kg bw/day) Cr exposed animals. Testicular histoarchitechture shows deterioration after critical dose (0.4 mg/kg bw/day) and duration (26 days) of Cr exposure. Cr induced alterations on testicular and adrenocortical activities are dose and duration dependent. Adrecortical hyperactivity accompanied by testicular oxidative stress might have a crucial role for Cr induced male reproductive impairment.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 24, Issues 3–4, November–December 2007, Pages 388–396
نویسندگان
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