کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2595328 1132312 2007 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of ERα overexpression on female reproduction in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Effects of ERα overexpression on female reproduction in mice
چکیده انگلیسی

Recently, we generated transgenic mice in which ERα can be inducibly overexpressed in reproductive tissues (ERα overexpressors). These mice were used to test the hypothesis that prenatal and postnatal ERα overexpression reduces female fertility. To do so, litter sizes, ovulation, follicle numbers, uterine histology, implantation sites, and hormone levels were compared in ERα overexpressors and controls. The data indicate that ERα overexpressors have reduced fertility compared to controls and that the reduced fertility is not due to reduced ovulatory capacity, altered levels of estradiol, FSH, and LH, or impaired follicular growth. ERα overexpressors, however, had a higher number of apoptotic cells in the endometrial epithelium and a reduced number of implantation sites compared to controls. Thus, the increased number of apoptotic cells and reduced number of implantation sites observed in ERα overexpressing uteri compared to controls may, in part, account for the reduced litter size produced by ERα overexpressing females.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Reproductive Toxicology - Volume 23, Issue 3, April–May 2007, Pages 317–325
نویسندگان
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