کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2596375 1132525 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticles
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Action potential changes associated with the inhibitory effects on voltage-gated sodium current of hippocampal CA1 neurons by silver nanoparticles
چکیده انگلیسی

Nano-sized materials are now being used in medicine, biotechnology, energy, and environmental technology. Although a wide and growing number of applications for nanomaterials exist, there are limited studies available on toxicity of nanoparticles for their human risk and environmental assessment. The aim of this study was to investigate the effects of silver nanoparticles (nano-Ag) on voltage-activated sodium currents in hippocampal CA1 neurons. Nano-Ag was tested at increasing concentrations (10−6, 5 × 10−6, 10−5 g/ml). The research results showed that only nano-Ag (10−5 g/ml) reduced the amplitude of voltage-gated sodium current (INa). The nano-Ag particles produced a hyperpolarizing shift in the activation–voltage curve of INa and also delayed the recovery of INa from inactivation. Action potential properties and the pattern of repetitive firing were examined using whole cell current-clamp recordings. Peak amplitude and overshoot of the evoked single action potential were decreased and half-width was increased in the present of the 10−5 g/ml nano-Ag solution, and the firing rate of repetitive firing had no change. The results suggest that nano-Ag may alter the action potential of hippocampal CA1 neurons by depressing voltage-gated sodium current.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 264, Issue 3, 29 October 2009, Pages 179–184
نویسندگان
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