کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2596752 | 1132547 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Crosstalk between activated forms of the aryl hydrocarbon receptor and glucocorticoid receptor
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کلمات کلیدی
EtOHIndeno[1,2,3-cd]pyreneMMTV-LTRBENGREANTBAPCyPAHRDEXDMSO - DMSOEthanol - اتانولind - اندرAnthracene - اینتگرین benzene - بنزنBenzo[a]pyrene - بنزو [a] پییرنDexamethasone - دگزامتازونDimethyl sulfoxide - دیمتیل سولفواکسیدAHRE - سالCytochrome P450 - سیتوکروم پی۴۵۰Naphthalene - نفتالینPolycyclic aromatic hydrocarbons - هیدروکربن آروماتیک چندحلقهایPAHs - هیدروکربن های آروماتیک چند حلقه ایPyrene - پیرنهaryl hydrocarbon receptor - گیرنده آرویل هیدروکربنglucocorticoid receptor - گیرنده گلوکوکورتیکوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Crosstalk between activated forms of the aryl hydrocarbon receptor and glucocorticoid receptor Crosstalk between activated forms of the aryl hydrocarbon receptor and glucocorticoid receptor](/preview/png/2596752.png)
چکیده انگلیسی
Pyrene, benzo[a]pyrene (BaP), and indeno[1,2,3-cd]pyrene (IND) are poly cyclic aromatic hydrocarbons (PAHs) with four to six annealed phenyl rings. Dexamethasone (Dex) is a synthetic agonist of glucocorticoids. The aryl hydrocarbon receptor (AhR) ligands, BaP and IND, did not directly activate the glucocorticoid receptor (GR), and Dex did not activate the AhR either. Whenever BaP and IND were added to Dex-treated cultures, they were present with Dex for longer periods, and higher enhancement of Dex-induced transactivation of the GR was found, which indicates that the freshly activated AhR is essential for synergistic interactions with the activated GR. The degree of enhancement of Dex-induced transactivation of the GR by PAHs, BaP â IND > pyrene, paralleled the potency of PAHs in activating the AhR. This synergistic interaction was more distinct in ovarian granulosa cells (HO23) than in HepG2, 293T, or HeLa cells. In contrast, Dex suppressed AhR-mediated expressions, including AhR and cytochrome P450 (CYP) 1 A1 expressions. Dex also counteracted the BaP-induced decrease in cell viability. Crosstalk between the AhR and GR was independent of their expression levels. We concluded that the AhR functionally cross-reacts with the GR, through which transactivation activity of the GR is further enhanced, and in contrast, transactivation activity of the AhR is inhibited. This report shows the significance of in vitro endocrine-related results, which provide a clue for molecular studies of an interactive mechanism between the AhR and GR, and should be confirmed by future in vivo studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 262, Issue 2, 3 August 2009, Pages 87-97
Journal: Toxicology - Volume 262, Issue 2, 3 August 2009, Pages 87-97
نویسندگان
Shao-Hung Wang, Chu-Ting Liang, Yi-Wen Liu, Min-Cong Huang, See-Chang Huang, Wei-Fu Hong, Jyan-Gwo J. Su,