کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2597844 | 1132604 | 2006 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The role of tumor necrosis factor α and the peroxisome proliferator-activated receptor α in modulating the effects of fumonisin in mouse liver
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کلمات کلیدی
FumonisinPPARTNFH&E - H & EWY-14,643 - O-14.643peroxisome proliferator - proliferator پروکسیومsphingolipids - اسفنگولیپیدHepatocyte proliferation - انتشار هپاتوسیتtumor necrosis factor α - تومور نکروز عامل αApoptosis - خزان یاختهایtumor necrosis factor - فاکتور نکروز تومورHematoxylin and Eosin - هماتوکسیلین و ائوزینperoxisome proliferator-activated receptor - گیرنده فعال فعال پروکسیومperoxisome proliferator-activated receptor α - گیرنده پروتئینی فعال پروکسایزوم α
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The role of tumor necrosis factor α and the peroxisome proliferator-activated receptor α in modulating the effects of fumonisin in mouse liver The role of tumor necrosis factor α and the peroxisome proliferator-activated receptor α in modulating the effects of fumonisin in mouse liver](/preview/png/2597844.png)
چکیده انگلیسی
Fumonisins are mycotoxins that are produced by Fusarium verticillioides found in corn and corn-based foods, and are suspected human esophageal carcinogens. Exposure of rodents to fumonisin B1 causes hepatotoxicity and results in alterations in the balance between cell proliferation and apoptosis in the liver. As the cytokine tumor necrosis factor α (TNFα) and the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) also modulate hepatocyte proliferation and apoptosis, we tested the hypothesis that fumonisin-induced hepatotoxicity in the liver is modulated by these factors. We examined the effects of dietary exposure to a fumonisin-containing culture material (CM) of the fungus F. verticillioides for 8 days or 5 weeks in the livers of mice lacking either TNFα or PPARα. Compared to wild-type mice TNFα-null mice exhibited increased hepatocyte proliferation and apoptosis. In contrast, PPARα-null and wild-type mice were found to exhibit similar patterns of hepatocyte apoptosis and proliferation when fed the CM diet. Overall, these findings provide evidence that TNFα, but not PPARα, plays a role in modulating fumonisin-induced hepatotoxicity in mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology - Volume 222, Issue 3, 15 May 2006, Pages 165-174
Journal: Toxicology - Volume 222, Issue 3, 15 May 2006, Pages 165-174
نویسندگان
Kenneth A. Voss, Ronald Riley, Corrie Dunn, J. Christopher Corton,