کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2598605 1562632 2016 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acute iron overload leads to hypothalamic-pituitary-gonadal axis abnormalities in female rats
ترجمه فارسی عنوان
اضافه بار آهن حاد منجر به اختلالات مغزی هیپوتالاموس-هیپوفیز گناد در موشهای صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
چکیده انگلیسی


• Acute iron overload accumulated in female rat hypothalamic-pituitary-gonadal axis
• Acute iron overload impairs hypothalamic-pituitary-gonadal axis morphophysiology
• Acute iron overload increased oxidative stress in pituitary, uterus and ovary in vivo.

Iron plays a critical role in a mammal’s physiological processes. However, iron tissue deposits have been shown to act as endocrine disrupters. Studies that evaluate the effect of acute iron overload on hypothalamic-pituitary-gonadal (HPG) axis health are particularly sparse. This study demonstrates that acute iron overload leads to HPG axis abnormalities, including iron accumulation and impairment in reproductive tract morphology. Female rats were treated with iron-dextran (Fe rats) to assess their HPG morphophysiology. The increasing serum iron levels due to iron-dextran treatment were positively correlated with higher iron accumulation in the HPG axis and uterus of Fe rats than in control rats. An increase in the production of superoxide anions was observed in the pituitary, uterus and ovary of Fe rats. Morphophysiological reproductive tract abnormalities, such as abnormal ovarian follicular development and the reduction of serum estrogen levels, were observed in Fe rats. In addition, a significant negative correlation was obtained between ovary superoxide anion and serum estrogen levels. Together, these data provide in vivo evidence that acute iron overload is toxic for the HPG axis, a finding that may be associated with the subsequent development of the risk of reproductive dysfunction.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 240, Issue 1, 5 January 2016, Pages 196–213
نویسندگان
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