5-Iodo-2-aminoindan (5-IAI): Chemistry, pharmacology, and toxicology of a research chemical producing MDMA-like effects

In 2010, an internet snapshot of EMCDDA anticipated the presence of 5-iodo-2-aminoindan (5-IAI) within the recreational drug market. In 2011, this compound, a psychoactive derivative of 2-aminoindane, was identified in recreational products sold in the United Kingdom. 5-IAI is a rigid analogue of p-iodoamphetamine producing MDMA-like effects. The aim of this paper is to summarize the clinical, pharmacological, and toxicological information about this new potential drug of abuse.

► 5-Iodo-2-aminoindan (5-IAI) is a new designer drug of abuse.
► This substance is marketed via online research chemicals stores.
► 5-IAI is used as alternative to other illicit club drugs.
► 5-IAI can produce MDMA-like effects.
► Preliminary evidence suggest a low risk of long term neurotoxicity.