کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2599537 1133214 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Anti-aging effects of deuterium depletion on Mn-induced toxicity in a C. elegans model
چکیده انگلیسی

Work with sub-natural levels of deuterium (D) in animals has demonstrated an anti-cancer effect of low D-concentration in water. Our objective was to investigate whether deuterium-depleted water (DDW) can overturn reverse manganese (Mn)-induced reduction in life span, using the Caenorhabditis elegans (C. elegans) as a model system. DDW per se had no effect on worm's life span 48 h after treatment; however, it reversed the Mn-induced decrease in C. elegans life span. Mn reduced DAF-16 levels, a transcription factor strongly associated with life-span regulation. Low D-concentration (90 ppm) restored the Mn-induced changes in DAF-16 to levels indistinguishable from controls, suggesting DDW can regulate the DAF-16 pathway. We further show that insulin-like receptor DAF-2 levels were unaltered by Mn exposure, tAKT levels increased, whilst superoxide dismutase (SOD-3) levels were decreased by Mn. DDW (90 ppm) restored the levels of tAKT and superoxide dismutase (SOD) to control values without changing DAF-2 levels. Treatment of Mn exposed worms with DDW (90 ppm) restored life-span, DAF-16 and SOD-3 levels to control levels, strongly suggesting that low D concentrations can protect against Mn toxic effects.


► Manganese exposure causes life span reduction in C. elegans.
► Manganese causes reduction in DAF-16 and SOD-3 levels.
► D-depletion treatment reverses the Mn-induced reduction in life-span caused by and restores DAF-16 levels to control values.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 211, Issue 3, 20 June 2012, Pages 319–324
نویسندگان
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