کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2599572 1133217 2012 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acute effects of exposure to vapors of hydrogen peroxide in humans
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Acute effects of exposure to vapors of hydrogen peroxide in humans
چکیده انگلیسی

Hydrogen peroxide is a reactive chemical mainly used for bleaching, as a disinfectant, and as a general oxidizing agent. The aim of this study was to investigate subtle acute effects of inhaled hydrogen peroxide vapors. Eleven healthy volunteers were exposed to 0 (clean air), 0.5 and 2.2 ppm for 2 h at rest. Symptoms related to irritation and central nervous system effects were rated with Visual Analog Scales. The ratings varied considerably but were generally low and with no significant differences between exposure conditions, although the ratings of smell (p = 0.09, Friedman's test), nasal irritation (p = 0.06) and throat irritation (p = 0.06) showed borderline tendencies to increase at 2.2 but not at 0 and 0.5 ppm. Nasal airway resistance increased after exposure to 2.2 ppm hydrogen peroxide (p = 0.04, paired t-test) but not after 0.5 ppm. No exposure-related effects on pulmonary function, nasal swelling, breathing frequency and blinking frequency were detected. Furthermore, no clear effects were seen on markers of inflammation and coagulation (interleukin-6, C-reactive protein, serum amyloid A, fibrinogen, factor VIII, von Willebrand factor and Clara cell protein in plasma). In conclusion, our study suggests that hydrogen peroxide is slightly irritating at 2.2 ppm, but not at 0.5 ppm.


► We studied the acute effects of inhaled hydrogen peroxide in humans.
► Volunteers were exposed to 0 ppm, 0.5 ppm or 2.2 ppm hydrogen peroxide for 2 h.
► Our study suggests that hydrogen peroxide is slightly irritating at 2.2 ppm.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 212, Issue 2, 20 July 2012, Pages 222–227
نویسندگان
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