Research chemicals marketed as legal highs: The case of pipradrol derivatives

Between 1997 and 2011, more than 200 new substances were notified through the early-warning system, with the record number of 49 novel molecules reported in 2011. The pattern of acute toxicity associated with the consumption of these new substances is generally similar to that seen with traditional drugs of abuse. Recently, a new class of synthetic stimulants closely related to pyrrolidine and piperidine compounds and known as pipradrol derivatives appeared in the recreational drug market. These substances, producing amphetamine-like effects, are used by people in substitution of traditional illicit drugs. The aim of this paper is to summarize the clinical, pharmacological and toxicological information currently available about this new class of synthetic drugs of abuse.

► Pipradrol, 2-DPMP, D2PM and desoxy-D2PM are a new class of designer drugs of abuse.
► These substances are marketed as legal highs.
► Pipradrol, 2-DPMP, D2PM and desoxy-D2PM are used as alternative to other illicit stimulants.
► These drugs can produce prolonged neuropsychiatric effects.
► Literature data suggest a high risk of central nervous and cardiovascular system toxicity.