کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2599775 1133227 2012 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Recent trends in biomonitoring of bisphenol A, 4-t-octylphenol, and 4-nonylphenol
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Recent trends in biomonitoring of bisphenol A, 4-t-octylphenol, and 4-nonylphenol
چکیده انگلیسی

Bisphenol A (BPA), 4-t-octylphenol (4-t-OP), and 4-nonylphenol (4-NP) are man-made alkylphenolic environmental contaminants possessing controversial endocrine disruption properties. Nowadays, an increased interest is raised for their accurate determination in biological media in order to estimate the exposure to these compounds and the associated health risk. The aim of this review is to present the available analytical methodologies for biomonitoring these three EDCs in human population. In non-occupational human exposure, they are detected in human matrices in trace level concentrations, commonly lower than 1 ng/mL. The use of mass spectrometry based methods is particularly emphasized due to their well known superiority over sensitivity, selectivity and precision, even in difficult matrices, such as blood plasma and serum. Recent and most applicable sample preparation techniques are thoroughly presented. The benefits of solid phase extraction (SPE) and expected developments are demonstrated. Recent results from exposure assessment and epidemiologic studies for BPA, 4-t-OP and 4-NP are summarized and future trends are discussed.


► A review of current analytical methodologies for biomonitoring of BPA, 4-t-OP and 4-NP in human media is presented.
► Mass spectrometric methods for modern bioanalysis are particularly emphasized.
► Trends in sample preparation and LC–MS methods are discussed and foreseen.
► Results from recent biomonitoring studies on 4-t-OP, 4-NP and BPA (2009 and onwards) are summarized.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 210, Issue 2, 25 April 2012, Pages 141–154
نویسندگان
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