کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2599863 1133233 2011 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Vascular tube formation and angiogenesis induced by polyvinylpyrrolidone-coated silver nanoparticles
چکیده انگلیسی

Silver nanoparticles (AgNPs) are one of the most commonly used nanomaterials due to their antibacterial properties. In this study, we examined the effects of polyvinylpyrrolidone (PVP)-coated AgNPs (average size 2.3 nm) on angiogenesis in both an in vivo model and an in vitro endothelial cell line, SVEC4-10. Increased angiogenesis was detected around the injection site of AgNP-containing Matrigel in vivo. AgNPs also increased the infiltration of endothelial cells and the hemoglobin (Hb) content in AgNP-Matrigel plugs implanted into mice. AgNPs induced endothelial cell tube formation on growth factor-reduced Matrigel, production of reactive oxygen species (ROS), and production of angiogenic factors, such as vascular endothelial growth factor (VEGF) and nitric oxide (NO), in SVEC4-10 cells. In addition, AgNPs promoted the activation of FAK, Akt, ERK1/2, and p38, which are all involved in VEGF receptor (VEGFR)-mediated signaling. Finally, AgNP-treated tumors caused angiogenesis around tumors in B16F10 melanomas after they were injected into mice, and the Hb concentration in the tumors increased in a concentration-dependent manner with AgNP treatment. Thus, our study suggests that exposure to AgNPs can cause angiogenesis through the production of angiogenic factors.


► We examine the effects of silver nanoparticles on angiogenesis.
► They induce angiogenesis and increase infiltration of endothelial cells.
► They induce endothelial cell tube formation and production of angiogenic factors.
► We provide evidence for the VEGFR signaling and increased angiogenesis of melanoma.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 205, Issue 3, 10 September 2011, Pages 227–234
نویسندگان
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