کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2599893 1133234 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of exposure to nanoparticle-rich diesel exhaust on adrenocortical function in adult male mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Effects of exposure to nanoparticle-rich diesel exhaust on adrenocortical function in adult male mice
چکیده انگلیسی

To investigate the effects of nanoparticle-rich diesel exhaust (NR-DE) on adrenocortical function, seven-week-old male mice were divided into four groups and exposed to either whole NR-DE at low (41.73 μg/m3, 8.21 × 105 particles/cm3), high (152.01 μg/m3, 1.80 × 106 particles/cm3) concentrations, filtered diesel exhaust (F-DE) or clean air for 8 weeks (5 h/day, 5 days/week). After 8 weeks of exposure, the animals were euthanized under pentobarbital anesthesia and the blood samples were collected to detect serum progesterone and corticosterone. In addition, adrenal glands were excised, and adrenal cells were cultured in the absence or presence of rat adrenocorticotropic hormone (ACTH) (10−15 to 10−10 M) for 4 h. There were no significant differences in the body weight, absolute and relative adrenal gland weight among the groups. Serum concentration of corticosterone and progesterone was not changed significantly. Administration of ACTH resulted in a dose-dependent increase in corticosterone and progesterone release in mice-exposed to low-concentration NR-DE and clean air. Moreover, corticosterone and progesterone concentrations in adrenal cells increased significantly in mice-exposed to low-concentration NR-DE basal and administrated with ACTH (10−15 to 10−11 M for corticosterone; 10−14 to 10−11 M for progesterone) compared with the control mice. In contrast, the concentration of corticosterone and progesterone decreased significantly in mice-exposed to high-concentration NR-DE or F-DE basal and administrated with ACTH (10−12 to 10−10 M for corticosterone; 10−15 to 10−10 M for progesterone) compared with the control mice. These results suggest that exposure to NR-DE or F-DE may disrupt adrenocortical function in adult male mice.


► Different concentrations of NR-DE were exposed to adult male mice.
► NR-DE disrupted the secretory ability of corticosterone and progesterone.
► Nanoparticle-rich diesel exhaust (NR-DE) effects on adrenocortical function.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 209, Issue 3, 25 March 2012, Pages 277–281
نویسندگان
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