کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2600447 1133265 2011 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Absence of adverse effect on thyroid function and red blood cells in a population of workers exposed to cobalt compounds
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Absence of adverse effect on thyroid function and red blood cells in a population of workers exposed to cobalt compounds
چکیده انگلیسی

ContextHypothyroidism has been observed in the fifties and sixties as an undesirable side-effect of cobalt therapy used for its erythropoietic properties in the treatment of anemia.ObjectiveThis study aims at evaluating the possible impact of both cumulative (long-term) and recent occupational exposure to cobalt on thyroid function and red blood cells.Methods and settingA cross-sectional survey was conducted from February 2008 to August 2009 in a population of 249 male workers from a cobalt production department in the North of Belgium. The possible effect of cobalt exposure on thyroid and red blood cells was investigated through multiple regression analyses.ResultsBlood cobalt ranged from undetectable to 3.20 μg/100 ml (median 0.10); urinary cobalt from 0.30 to 204.30 μg/gcreat (median 3.90) and long-term exposure to cobalt ranged from 0.15 to 6990.46 μg/gcreat·years (median 106.09). No effect of cobalt exposure on thyroid or red blood cell parameters was observed at these levels of exposure.ConclusionThe results support the absence of effects on the thyroid and red blood cells when occupational exposure to cobalt is kept below the recommended biological limit of occupational exposure (15 μg Co/gcreat in urine).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 201, Issue 1, 25 February 2011, Pages 42–46
نویسندگان
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