کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2600650 1133278 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Acute cardiac dysfunction after short-term diesel exhaust particles exposure
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Acute cardiac dysfunction after short-term diesel exhaust particles exposure
چکیده انگلیسی

Epidemiological studies show an association between particulate matter exposure and acute heart failure. However, underlying mechanisms remain unclear. In this study, we investigated acute cardiac hemodynamic effects and related mechanisms after 1 day exposure to diesel exhaust particles (DEPs). Male Sprague–Dawley rats were randomized and instilled with 250 μg (low dose) or 500 μg (high dose) of DEP or saline placebo intra-tracheally. The cardiac systolic function by dP/dt40 and diastolic functions by maximal negative dP/dt were both worse in DEP low dose and DEP high dose groups than the control group, respectively. In the heart rate variability analysis, SDNN in DEP low dose and DEP high dose groups were both lower than the control group. The low frequency heart rate variability was higher in the DEP groups compared to the control group. The cardiac IL-1β expression and circulating cardiac troponin I level were higher in the DEP group than the control group. Plasma IL-1β and IL-6 protein were significantly higher in the DEP groups than the control group. In conclusion, DEP exposure causes acute cardiac systolic and diastolic dysfunction. The changes may be related to decreased heart rate variability, increased cardiac inflammatory reaction and myocardial damage.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 192, Issue 3, 15 February 2010, Pages 349–355
نویسندگان
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