In vivo and in vitro characterization of ethyl methanesulfonate pharmacokinetics in animals and in human

Following administration of Viracept tablets of the contaminated production batches (to monkeys leading to EMS doses of 0.08-27 μg/kg, concentrations of ethyl-valine Hb adducts) were near or below the detection limit of the assay (0.043 nmol/g Hb).