کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2601129 | 1133301 | 2006 | 7 صفحه PDF | دانلود رایگان |
Lysine derivative surfactants are a class of amino acid-based surfactants synthesized as lecithin analogues that deserve particular attention because of their low toxicity and high biocompatibility. To complete the toxicological profile of these surfactants, IL-1α production (cell-associated and release to the culture medium) was determined as an in vitro method for predicting skin irritation. In addition, an MTT assay was used as a viability marker in keratinocytes NCTC 2544. Keratinocytes are a biologically relevant target for developing in vitro techniques to assess skin irritants: moreover, they are the principal source of the proinflammatory cytokine IL-1α in the epidermis. Lysine derivatives proved to be less potent in stimulating IL-1α synthesis and induced a lower release of this cytokine into the culture medium when compared to the anionic surfactant sodium dodecyl sulfate. Due to their low irritancy potential, lysine-based surfactants may offer promising applications in pharmaceutical and cosmetic preparations.
Journal: Toxicology Letters - Volume 167, Issue 1, 1 November 2006, Pages 40–46