کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2601349 1562645 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cadmium exerts toxic effects on ovarian steroid hormone release in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Cadmium exerts toxic effects on ovarian steroid hormone release in rats
چکیده انگلیسی

This study examined the toxic effects of cadmium on the function of sexual hormone release in the ovaries of rats and the mechanism of this dysregulation. In vivo, adult female rats were randomly assigned to four groups based on weight. Cadmium was given ip 5 days/week for 6 weeks at doses of 1.0, 0.5, 0.25 and 0 mg/kg. Following euthanasia, the ovaries were removed and placed into culture medium for 3 h. The levels of progesterone (P) and estadiol (E) in the culture medium were then measured by radioimmunoassay. In vitro studies were done using the ovaries of adult rats in different stages of estrous (proestrus, estrus, metestrus and diestrus). Individual ovaries were collected, placed into culture medium and exposed to 0, 0.1, 1, or 2 mM of CdCl2 for 3 h, at which time the levels of P and E in the ovary culture serum were determined by radioimmunoassay. The in vivo results showed that the levels of P and E in the ovary culture serum (5.3 ± 1.4 ng/ml and 1.4 ± 0.4 pg/ml, respectively) decreased significantly in the high dose group compared to the control (9.2 ± 0.9 ng/ml and 3.9 ± 0.7 pg/ml, respectively). In vitro, there were significant differences in P and E in between the different concentrations of cadmium and also between the different stages of the estrous cycle. These data suggest that cadmium can inhibit P and E release in ovaries. This may represent an important mechanism of endocrine disruption.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 182, Issues 1–3, 10 November 2008, Pages 18–23
نویسندگان
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