کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2601378 1133316 2008 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Estimation of benchmark doses as threshold levels of urinary cadmium, based on excretion of β2-microglobulin in cadmium-polluted and non-polluted regions in Japan
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Estimation of benchmark doses as threshold levels of urinary cadmium, based on excretion of β2-microglobulin in cadmium-polluted and non-polluted regions in Japan
چکیده انگلیسی

The threshold level of urinary cadmium (Cd) for β2-microglobulin (MG)-uria was calculated using a benchmark dose (BMD) approach. Total number of subjects was 3103 for Cd-polluted areas and 2929 for non-polluted areas. Multiple logistic regression analysis was employed to fit the dose–response model taking into consideration an age effect. Cut-off values for urinary β2-MG were defined as those corresponding to the 84th and 97.5th percentile of β2-MG levels in the controls, and 1000 μg/g creatinine (cr). The BMD low (BMDL) was calculated using the profile likelihood method. When the benchmark response was 5%, the BMD/BMDL of Cd for the 84th percentile of β2-MG for mean age, 55, 65, and 75 years was 3.0/2.7, 4.6/4.2, 2.8/2.6, and 1.8/1.6 μg/g cr in men and 3.4/3.2, 5.8/5.5, 3.2/3.1, and 1.8/1.7 μg/g cr in women, respectively. The value for the 97.5th percentile for each age was 4.9/4.5, 7.6/7.0, 4.6/4.3, and 2.6/2.4 μg/g cr in men and 5.9/5.6, 9.7/9.2, 5.6/5.3, and 2.8/2.6 μg/g cr in women. Namely it became clear that the margin between the threshold level and average excretion level of urinary Cd was small in the older population in Japan. To prevent the adverse health effects caused by exposure to Cd, it is important to establish the threshold level of Cd exposure at each age.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 179, Issue 2, 30 June 2008, Pages 108–112
نویسندگان
, , , , , , ,