کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2601655 1133338 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The inhalation exposure of carbon tetrachloride promote rat liver carcinogenesis in a medium-term liver bioassay
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The inhalation exposure of carbon tetrachloride promote rat liver carcinogenesis in a medium-term liver bioassay
چکیده انگلیسی

The potential of carbon tetrachloride (CCl4) to induce pre-neoplastic lesions in rat liver using a medium-term liver assay (Ito method) for the prediction of carcinogenicity was examined by nose-only inhalation exposure of male rats (15/group) to CCl4 vapor at concentrations of 0, 1, 5, 25, 125 ppm for 6 h/day, 6 day/week, for a period of 6 weeks. The numbers and area of glutathione S-transferase placental (GST-P) positive foci were then determined. Additionally, other histopathological observations on the livers were recorded and serum chemical parameters and CCl4 concentrations in blood were measured. The areas and numbers of GST-P positive foci significantly increased in the CCl4-exposed rats at 25 and 125 ppm; but not at concentrations of 1 and 5 ppm. CCl4 blood concentration 24 h after initiation of exposure in the 125 ppm group remained at about 5% of the 6 h maximum concentration. These data from CCl4-exposed rats clearly show that inhalation exposure can be used in the rat medium-term liver assay, the method is available for the screening of volatile chemicals and is therefore a useful tool in cancer risk assessment. This is the first report of the use of inhalation exposure in this medium-term predictive assay.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology Letters - Volume 176, Issue 3, 15 February 2008, Pages 207–214
نویسندگان
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