کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2603300 | 1133816 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Genotoxic effects in human lymphocytes exposed to arsenic and vitamin A Genotoxic effects in human lymphocytes exposed to arsenic and vitamin A](/preview/png/2603300.png)
Arsenic is a ubiquitous trace element and a well-established human carcinogen. In search for an ‘antidote’ to this global poison, this work was undertaken to study the probable beneficial effect of vitamin A upon arsenic induced genotoxicity. Peripheral blood lymphocyte culture was carried out to study the effects of arsenic at three different dose levels (0.5, 1 and 2 μg) for 24 h prior to harvesting. In addition, mutagenic in vitro effect of ethyl methanesulphonate was studied as a positive control. Genotoxic variables presented here are sister chromatid exchanges (SCE), cell cycle proliferative index/replicative index (CCPI/RI), average generation time (AGT) and population doubling time (PDT). Inevitably, arsenic treatment showed dose-dependent augmentation in the incidences of SCE and CCPI/RI together with AGT and PDT. However, vitamin A supplemented arsenic cultures demonstrated remarkable resurgence in the described genotoxic parameters. This data shows that vitamin A might be a useful interventional treatment in arsenic poisoning.
Journal: Toxicology in Vitro - Volume 21, Issue 4, June 2007, Pages 626–631