کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2603480 | 1133821 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The chorioallantoic membrane test as a model to predict the potential human eye irritation induced by commonly used laboratory solvents
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The purpose of this study was to investigate the potential eye irritation of a range of solvents, extensively used in industry and laboratory and the capacity of the chorioallantoic membrane test to predict this eye irritation. The irritation has been evaluated by an in vitro method using the chorioallantoic membrane as an alternative to in vivo Draize rabbit test. All the solvents studied are potentially strongly irritants, even though diluted, except dimethyl sulfoxide which was moderately irritant at a concentration of 10% v/v. In some cases there is a correlation between the concentration of the solvent and the potential eye irritation induced. The method allows prediction of the potential eye irritation of the solvents studied.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 20, Issue 6, September 2006, Pages 1066–1070
Journal: Toxicology in Vitro - Volume 20, Issue 6, September 2006, Pages 1066–1070
نویسندگان
M.P. Vinardell, M. Mitjans,