کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2603776 | 1133835 | 2007 | 6 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Vitamin-E reduces the oxidative damage on δ-aminolevulinic dehydratase induced by lead intoxication in rat erythrocytes Vitamin-E reduces the oxidative damage on δ-aminolevulinic dehydratase induced by lead intoxication in rat erythrocytes](/preview/png/2603776.png)
Lead intoxication induces oxidative damage on lipids and proteins. In the present paper we study in vivo and in vitro the antioxidant effect of vitamin-E and trolox, on the oxidative effects of lead intoxication in rat erythrocytes. Vitamin-E simultaneously administered to erythrocytes treated with lead was capable to prevent the inhibition of δ-aminolevulinic dehydratase activity and lipid oxidation. Partial but important protective effects were found when vitamin-E was administered either after or before lead exposure in rats. In vitro, the antioxidant trolox protected δ-ALA-D activity against damage induced by lead or menadione. These results indicate that vitamin-E could be useful in order to protect membrane-lipids and, notably, to prevent protein oxidation produced by lead intoxication.
Journal: Toxicology in Vitro - Volume 21, Issue 6, September 2007, Pages 1121–1126