کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2603794 1133838 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The concentration-dependent induction of cell death by trimethyltin chloride in rat liver epithelial IAR20 cells
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
The concentration-dependent induction of cell death by trimethyltin chloride in rat liver epithelial IAR20 cells
چکیده انگلیسی

In this study we intended to evaluate the cytotoxic and genotoxic effects of trimethyltin chloride (TMT), one of the most widely used organometallic compounds, on liver cells with the rat liver epithelial cell line IAR20. The results showed that TMT significantly inhibited cell growth in a concentration-dependent manner and caused an increase in DNA damage. Additionally, Hoechst 33342 staining and flow cytometry detected increases in apoptotic and necrotic cells. Western blots demonstrated that the Bcl-2 family of proteins was involved in the apoptotic process, but p53 was not concerned.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 22, Issue 5, August 2008, Pages 1136–1142
نویسندگان
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