کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2603906 1133845 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In vitro evaluation of oxidative damage from organic solvent vapours on human skin
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
In vitro evaluation of oxidative damage from organic solvent vapours on human skin
چکیده انگلیسی
An in vitro model was optimized to evaluate the viability and integrity of the barrier function of human skin following occupational exposure to solvent vapours. To evaluate the role of oxidative stress, the antioxidant status of skin and some biomarkers of oxidative damage as lipid and protein peroxidation products and DNA fragmentation were also studied. It was investigated if decreasing concentrations of styrene, toluene, acetone, xylene and perchloroethylene vapours, up to be comparable to the TLV-TWA, were able to damage skin integrity. Solvent vapours reduced tissue viability and impaired skin barrier function, as indicated by the increase of transepidermal water loss. Reduced glutathione depletion, decreased activity of antioxidant enzymes and oxidative damage of biological macromolecules were also observed. The overall trend of these results indicates that the tested compounds damage human skin even at concentrations comparable to their TLV, and that oxidative stress is involved in these effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 20, Issue 3, April 2006, Pages 324-331
نویسندگان
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