کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2603975 | 1133854 | 2006 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay Evaluation of apigenin using in vitro cytochalasin blocked micronucleus assay](/preview/png/2603975.png)
چکیده انگلیسی
High doses of flavonoids are reported to be clastogenic in contrast to their potential to reduce oxidative DNA damage, retard growth of leukemia cells, obstruct cell signal transduction and induce cellular differentiation in cancers. In the present study, we evaluated apigenin, a plant-derived flavonoid in doses of 10, 33, and 100 μM per 5 ml culture using cytochalasin-B blocked micronucleus (CBMN) assay in peripheral human lymphocytes. Apigenin was found to induce micronuclei in a dose dependent manner indicating potential genotoxic hazard in humans. Hence, flavonoids may act as mutagen, pro-oxidant or as inhibitor of key enzymes to produce clastogenic effects depending upon the levels consumed as well as the physiological parameters.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 20, Issue 7, October 2006, Pages 1168–1172
Journal: Toxicology in Vitro - Volume 20, Issue 7, October 2006, Pages 1168–1172
نویسندگان
Sanjeev Noel, Madhu Kasinathan, Srikanta Kumar Rath,