کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
2639305 1563488 2014 5 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Long-term carriage of Klebsiella pneumoniae carbapenemase–2-producing K pneumoniae after a large single-center outbreak in Germany
ترجمه فارسی عنوان
حمل طولانی مدت K-pneumoniae تولیدکننده carbapenemase-2 Klebsiella pneumoniae پس از شیوع یک مرکز بزرگ در آلمان
کلمات کلیدی
KPC؛ کلونی سازی روده؛ حمل طولانی مدت. فشار انتخاب؛ سرکوب سیستم ایمنی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
چکیده انگلیسی

BackgroundThe natural progress of intestinal colonization with Klebsiella pneumoniae carbapenemase–2-producing K pneumoniae (KPC-2-KP) is almost unknown.MethodsAfter a large, single-center outbreak of KPC-2-KP, we analyzed carrier prevalence through retrospective and prospective investigation of intestinal KPC-2-KP carriage 1 month, 3 months, 6 months, 1 year, and 2 years after acquisition, defined as the earliest date of KPC-2-KP detection. Rectal swabs or stool samples were collected at baseline and at each visit and submitted for both culture and KPC-specific polymerase chain reaction. Resolution of intestinal KPC-2-KP carriage was defined as a minimum of 3 consecutive negative polymerase chain reaction test results separated by at least 48 hours.ResultsIn patients available for long-term evaluation 26 out of 84 patients (31%) tested negative for KPC-2-KP after 1 month, 14 out of 34 (41%) after 3 months, 17 out of 26 (65%) after 6 months, 14 out of 19 (74%) after 1 year, and 5 out of 6 (83%) after 2 years. Decolonization of KPC-2-KP was hampered in patients with prolonged or repeated hospitalization (P = .044-.140, depending on the time interval). Two patients retested positive for KPC-2-KP after they had previously shown 3 consecutive negative tests. The longest positive KPC-2-KP carrier status so far was observed after nearly 40 months (1,191 days).ConclusionsThe majority of patients experienced spontaneous decolonization within 6 months after acquisition, mainly after discharge from the hospital. However, long-term carriage of >3 years is possible. Appropriate infection control measures must be taken when these patients are readmitted to health care facilities. A series of at least 4 consecutive negative rectal swabs or stool samples separated by sufficient time intervals appears necessary before the declaration of successful KPC-2-KP decolonization is made.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: American Journal of Infection Control - Volume 42, Issue 4, April 2014, Pages 376–380
نویسندگان
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