Evidence-based Evaluation of Cholinesterase Inhibitors for Mild Cognitive Impairment

The purpose of this article is to critically appraise the evidence concerning the use of cholinesterase inhibitors compared to no treatment to prevent the progression from mild cognitive impairment (MCI) to Alzheimer disease. The objective was addressed through the development of a structured, critically appraised topic (CAT). This evidence-based methodology incorporated a clinical scenario, background information, structured question, literature search strategy, results, critical appraisal, commentary, and clinical bottom line.