کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2670821 1141312 2011 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dried gamma-irradiated amniotic membrane as dressing in burn wound care
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی مراقبت های ویژه و مراقبتهای ویژه پزشکی
پیش نمایش صفحه اول مقاله
Dried gamma-irradiated amniotic membrane as dressing in burn wound care
چکیده انگلیسی

RationaleDried amniotic membrane contains collagen matrix and key bioactive molecules like fibronectin, laminin, glycosaminoglycans and elastin. Fresh and cryopreserved human amniotic membrane has been widely explored as a biological dressing. However, fresh and cryopreserved amniotic membranes are not readily available or require special storage conditions. This investigation was aimed to study the functional and clinical efficacy of air-dried radiation sterilized amniotic membranes as dressing in burn wound care.MethodsAmniotic membranes collected from placentae of screened donors were processed and sterilized by gamma radiation at 25 kGy. The fluid handling capacity, shelf life and clinical efficacy of air-dried gamma-irradiated amniotic membranes was evaluated.ResultsFluid handling capacity of the air-dried irradiated amniotic membrane dressing was 3.79–4.2 g/10 cm2 in 24 h. Infrared (IR) spectral scanning showed no degradation or change in the dried gamma-irradiated amniotic tissue after 2 and 5 years of storage. No effect of storage on the impermeability of the processed amniotic membranes to bacteria was observed. The dried gamma-irradiated amniotic membranes even after 5 years of storage provided an effective barrier to microbial penetration. The dried amniotic membranes were applied to 22 cases of scald, flame and electrical burns. Of the 22 patients studied, 19 patients had excellent results in the form of complete epithelialization of wound with an average healing time of 15–25 days.ConclusionIR studies and microbial permeability test indicate no qualitative changes in the material property of dried gamma-irradiated amniotic membranes after 2 and 5 years of storage. Air-dried amniotic membrane with the advantage of storage at room temperature as well as functional efficiency is an ideal dressing for burn wound care.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Tissue Viability - Volume 20, Issue 2, May 2011, Pages 49–54
نویسندگان
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