کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2683209 | 1142622 | 2010 | 4 صفحه PDF | دانلود رایگان |
SummaryBackground & aimsMultiple myeloma (MM) ranks among the most frequent blood cancers in adults. Optimal treatment consists of high-dose chemotherapy and autologous stem cell transplantation. Health-related quality of life (HRQoL) is reduced before, during, and after therapy. Several HRQoL items are associated with nutritional health, e.g., nausea/vomiting, appetite loss and fatigue. It is unknown whether nutritional status in MM is affected by treatment. Hence we assessed nutritional status before, during and ½ year after treatment-start.MethodsWe applied anthropometry (height, weight, hand-grip strength, triceps skinfold) and plasma concentrations of biomarkers to assess nutritional status. HRQoL was determined with the EORTC QLQ-C30 questionnaire.ResultsThe anthropometrical parameters all decreased (p < 0.05) during treatment, but were restored at the end of the observation period. Albumin and the fat-soluble vitamins D and E followed a similar pattern, whereas transferrin and vitamin A were unchanged (p > 0.05). Interestingly, markers of thyroid function declined and remained low (p < 0.05) even 6 months after start of therapy. Nutrition-associated symptoms used as markers of HRQoL worsened during therapy, but returned to pre-therapy levels.ConclusionIntensive therapy in MM is associated with a decline in both nutritional status and health-related quality of life.
Journal: Clinical Nutrition - Volume 29, Issue 4, August 2010, Pages 488–491