کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2683644 1142674 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immunomodulatory activity of isoflavones isolated from Iris kashmiriana: Effect on T-lymphocyte proliferation and cytokine production in Balb/c mice
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی غدد درون ریز، دیابت و متابولیسم
پیش نمایش صفحه اول مقاله
Immunomodulatory activity of isoflavones isolated from Iris kashmiriana: Effect on T-lymphocyte proliferation and cytokine production in Balb/c mice
چکیده انگلیسی

This study deals with the evaluation of immunomodulatory action of a new isoflavone isonigricin (1) and first report isoirisolidone (2) isolated from rhizomes of Iris kashmiriana. Flowcytometric method was employed to study their effect on production of T-lymphocytes (CD4+ and CD8+ T-cells) and T-cell cytokines (IL-2, IL-4 and IFN-γ) in a dose-dependant manner. Drugs at doses of 0.025 to 0.8 mg/kg per oral dose showed compound 1 to possess immunosuppressant activity on T-cells as well as cytokines, while compound 2 acted as immunostimulator for both cells and cytokines. However, their methylated products viz. 1OMe and 2OMe exhibited stimulatory effect on interleukins under study and suppressive effect on production of T-lymphocytes and IFN-γ. The oral LD50 in mice was observed to be more than 200 mg/kg body weight. Such a difference in their activity is the manifestation of the position and nature of substituents present on isoflavonoidal skeleton and demonstrates the potential of these isolates as prospective immunomodulatory agents.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biomedicine & Preventive Nutrition - Volume 3, Issue 2, April–June 2013, Pages 151–157
نویسندگان
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