کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2750906 1149375 2010 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role of Anemia Prior to Radiation Treatment in Local Recurrence and Survival After Breast Conservation Treatment for Early-Stage Breast Cancer
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
Role of Anemia Prior to Radiation Treatment in Local Recurrence and Survival After Breast Conservation Treatment for Early-Stage Breast Cancer
چکیده انگلیسی

BackgroundAnemia is common among patients with newly diagnosed cancer, may be exacerbated by cancer therapies, and leads to radioresistance by lowering oxygen levels in the tumor microenvironment. Herein, the effect of breast irradiation on hemoglobin levels and outcomes in breast conservation therapy is reported.Patients and MethodsMedical records of 1368 women with stage 0, I, and II breast cancer treated with breast conservation therapy from 1977–2002 were reviewed. Hemoglobin levels at baseline as well as during and after radiation were recorded. Patterns of hemoglobin changes and the effect of anemia on local control and survival outcomes were assessed. Median follow-up time was 8 years for the normal group and 6 years for the anemic group.ResultsBaseline anemia was seen in 18% of the patients, 90% of whom had mild anemia (hemoglobin, 11.9–10.0 g/dL). Anemia was recorded in 21% during radiation. Among patients with normal baseline hemoglobin levels, 6.5% of the patients became anemic during radiation. Of those with baseline anemia, 72% had stable to improved hemoglobin levels during radiation, and 22% declined by a median of 0.3 g/dL. There were no significant differences in local or regional recurrence, overall, disease-free, cause-specific, or distant disease-free survival between patients with baseline anemia or with normal hemoglobin.ConclusionRadiation does not contribute significantly to anemia during breast conservation treatment, and mild anemia does not affect outcomes. It is unnecessary to obtain routine hemoglobin levels during radiation therapy. There is no difference in outcomes based on hemoglobin levels; thus, there is no reason to transfuse or provide erythropoiesis-stimulating agents for hemoglobin levels > 10 g/dL during radiation treatment of the breast.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Breast Cancer - Volume 10, Issue 1, February 2010, Pages 74–80
نویسندگان
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