Influence of Groin Incision, Duration of Ischemia, and Prostaglandin E1 on Ischemia-Reperfusion Injury of the Lower Limb

Conclusion: Development of edema during I/R depends on groin incision of the hind limb and on the duration of ischemia. The I/R injury is attenuated by PGE1 treatment, in terms of reduced edema formation and CK release, but not in terms of neuromuscular function.