Intrathecal administration of antioxidants attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat

► Mechanical pain hypersensitivity was increased in the sleep-deprived rat. ► Intrathecally administered antioxidants reduced hypersensitivity in sleep-deprived animals. ► Spinal oxidative stress contributes to pain hypersensitivity induced by sleep deprivation.