کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2772029 1151797 2007 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
PON1, A New Biomarker of Cardiovascular Disease, Is Low in Patients with Systemic Vasculitis
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیهوشی و پزشکی درد
پیش نمایش صفحه اول مقاله
PON1, A New Biomarker of Cardiovascular Disease, Is Low in Patients with Systemic Vasculitis
چکیده انگلیسی

ObjectivesBecause systemic vasculitis (SV) predisposes to atherosclerosis, and high-density lipoprotein (HDL) prevents atherosclerosis by “reverse cholesterol transport” and by inhibiting low-density lipoprotein (LDL) oxidation thanks to apolipoprotein A-I (Apo-AI) and paraoxonase 1 (PON1), we assessed whether LDL oxidation was increased in SV and associated with less PON1 activity.MethodsThe sera of 33 patients with active SV (ASV), 32 in full remission of SV (RSV) and 20 healthy subjects (HS) were analyzed for C-reactive protein (CRP), high-sensitivity-CRP, lipids, lipoproteins, apolipoproteins, PON1 activity, LDL-immune complexes (LDL-IC), and auto-antibodies to oxidized-LDL (ox-LDL), and anticardiolipin antibodies.ResultsCRP was higher in ASV than RSV and HS, and negatively correlated with HDL-cholesterol and Apo-AI. Autoantibodies to ox-LDL and highly oxidized malondialdehyde-LDL were higher in RSV than ASV and HS (P < 0.05). LDL-IC titers were higher in ASV than RSV and HS (P < 0.05). PON1 activity was lower in ASV and RSV than HS (P = 0.02). A trend toward a negative correlation between basal PON1 activity and anti-MDA-LDL antibodies (P = 0.06) was observed.ConclusionInflammatory markers in SV were associated with a modified lipoprotein profile, which could lower PON1 activity and contribute to increased ox-LDL titers and accelerated atherosclerosis development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seminars in Arthritis and Rheumatism - Volume 37, Issue 3, December 2007, Pages 149–155
نویسندگان
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