کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2779317 | 1153266 | 2012 | 6 صفحه PDF | دانلود رایگان |

We report here differences in the fatty acid profile of cancellous bone matrix, including n-3, n-6, mono- and poly-unsaturated, as well as saturated fats, between femoral heads from female OA (n = 8, aged 68–88 years), fractured neck of femur (#NOF) (n = 19, 67–88 years) and autopsy controls (CTRL) (n = 4, 85–97 years). Femoral heads were collected from individuals undergoing orthopaedic surgery for OA or #NOF; the fatty acid profile of sub-samples from the superior principal compressive and superior principal tensile regions were determined by gas chromatography. A total of 42 individual fatty acids were detected at varying concentrations with significant differences between subchondral bone from OA subjects, subchondral bone from #NOF subjects and subchondral bone from CTRL subjects, as well as between the superior principal compressive and superior principal tensile regions (for saturated fats only).Subchondral bone from OA subjects had higher total n-6 (OA = 10.89 ± 3.17, #NOF = 11.11 ± 1.83, CTRL = 8.32 ± 2.05, p = 0.008) and total n-3 (OA = 1.34 ± 0.38, #NOF = 1.19 ± 0.18, CTRL = 1.15 ± 0.48, p = 0.011) percentages than subchondral bone from #NOF subjects and subchondral bone from CTRL subjects, and there was no difference in the n-6:n-3 ratio, nor within the percentage of n-9 fatty acids. Arachidonic acid (OA = 0.42 ± 0.16, #NOF = 0.26 ± 0.06, CTRL = 0.28 ± 0.06, p = 0.01), and γ-linolenic acid (OA = 0.11 ± 0.03, #NOF = 0.05 ± 0.02, CTRL = 0.04 ± 0.02, p < 0.001) were higher in subchondral bone from OA subjects than subchondral bone from #NOF subjects and subchondral bone from CTRL subjects. In conclusion, there is a wide diversity of fatty acids in cancellous bone matrix from the femoral heads of OA and #NOF, suggesting they may have regulatory effects on inflammatory processes, and their metabolites.This article is part of a Special Issue entitled “Osteoarthritis”.
► The femoral subchondral bone matrix in situ total fat content of osteoarthritic and non-OA subjects differ.
► n-3, n-6 and n-9 fatty acid profiles differ between OA and non-OA groups.
► Differential fatty acid profiles may modulate inflammatory processes influencing subchondral bone remodelling, hence, the onset and progression of OA.
Journal: Bone - Volume 51, Issue 2, August 2012, Pages 218–223