کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2779320 1153266 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effects of aging on articular cartilage homeostasis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Effects of aging on articular cartilage homeostasis
چکیده انگلیسی

This review is focused on aging-related changes in cells and extracellular matrix of the articular cartilage. Major extracellular matrix changes are a reduced thickness of cartilage, proteolysis, advanced glycation and calcification. The cellular changes include reduced cell density, cellular senescence with abnormal secretory profiles, and impaired cellular defense mechanisms and anabolic responses. The extracellular and cellular changes compound each other, leading to biomechanical dysfunction and tissue destruction. The consequences of aging-related changes for joint homeostasis and risk for osteoarthritis are discussed.This article is part of a Special Issue entitled “Osteoarthritis”.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bone - Volume 51, Issue 2, August 2012, Pages 241–248
نویسندگان
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