کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2785687 | 1568385 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Abnormal transsulfuration metabolism and reduced antioxidant capacity in Chinese children with autism spectrum disorders
ترجمه فارسی عنوان
متابولیسم ترانس سولفوراسیون غیرطبیعی و کاهش ظرفیت آنتی اکسیدانی در کودکان چینی با اختلالات طیف اوتیسم
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کلمات کلیدی
GSSGCBSRFCHcyIQRCysBHMTMTHFRNACGSHtGSHABCGSH/GSSG - GSH / GSSGN-acetylcysteine - N-استیل سیستئینautism spectrum disorders - اختلالات طیف اوتیسمAutism spectrum disorder - اختلالات طیف اوتیسم گروهیstandard deviation - انحراف معیارbetaine-homocysteine methyltransferase - بتائین-هموسیستئین متیل ترانسفرازOxidative stress - تنش اکسیداتیوCysteine - سیستئینcystathionine β-synthase - سیستاتیونین β-سنتازCARS - ماشین هاMethylenetetrahydrofolate reductase - متیلن تتراهیدروفولات ردوکتازinterquartile range - محدوده بین محدبChildhood Autism Rating Scale - مقیاس رتبه بندی اوتیسم دوران کودکیASD - نقص سپتوم یا دیوارهی دهلیزیhomocysteine - هوموسیستئینChinese - چینی هاReduced folate carrier - کاهش دهنده فولاتreduced glutathione - کاهش گلوتاتیونoxidized glutathione - گلوتاتیون اکسید شدهtotal glutathione - گلوتاتیون کل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
چکیده انگلیسی
Autism spectrum disorder (ASD) is a neurological disorder that presents a spectrum of qualitative impairments in social interaction, communication, as well as restricted and stereotyped behavioral patterns, interests, and activities. Several studies have suggested that the etiology of ASD can be partly explained by oxidative stress. However, the implications of abnormal transsulfuration metabolism and oxidative stress, and their relation with ASD are still unclear. The purpose of this study was to evaluate several transsulfuration pathway metabolites in Chinese participants diagnosed with ASD, to better understand their role in the etiology of this disorder. Fifty children (39 male, 11 female) diagnosed with ASD and 50 age- and gender-matched non-ASD children (i.e., control group) were included in this study. This prospective blinded study was undertaken to assess transsulfuration and oxidative metabolites, including levels of homocysteine (Hcy), cysteine (Cys), total glutathione (tGSH), reduced glutathione (GSH), oxidized glutathione (GSSG), and glutathione ratio (GSH/GSSG). The clinical severity of ASD was evaluated with the Childhood Autism Rating Scale (CARS), and the autistic children's present behavior was measured by the Autism Behavior Checklist (ABC). The results indicated that Hcy and GSSG levels were significantly higher in children diagnosed with ASD, Cys, tGSH and GSH levels as well as the GSH/GSSG ratio showed remarkably lower values in ASD children compared to control subjects. Hcy levels correlated significantly with increasing CARS scores and GSSG levels in children with ASD. Our results suggest that an abnormal transsulfuration metabolism and reduced antioxidant capacity (i.e., hyperhomocysteinemia and increased oxidative stress), and Hcy level appears to have a potentially negative impact on clinical severity of autistic disorder.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 46, November 2015, Pages 27-32
Journal: International Journal of Developmental Neuroscience - Volume 46, November 2015, Pages 27-32
نویسندگان
Yu Han, Qian-qian Xi, Wei Dai, Shu-han Yang, Lei Gao, Yuan-yuan Su, Xin Zhang,