کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2786953 1568435 2009 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شناسی تکاملی
پیش نمایش صفحه اول مقاله
Expression of the homeobox genes PAX6, OTX2, and OTX1 in the early human fetal retina
چکیده انگلیسی

We studied the spatial and temporal expression of the homeobox genes PAX6, OTX2, and OTX1 using a developmental series of human fetal eyes aged from 6 to 10 weeks post-conception. Previous animal studies have shown that PAX6 may regulate progenitor cell proliferation, timing of differentiation and neural retina cell fate determination. OTX2 may play a role in development of the retinal pigment epithelium and photoreceptor differentiation, whereas OTX1 may be important in ciliary body development.In this study, we demonstrate the presence of the mRNAs and proteins for these genes within human fetal retinas of different stages. By in situ hybridization and immunohistochemistry, we show that PAX6 was primarily localized to nuclei of the neural retina, OTX2 was localized to the nuclei of retinal pigment epithelium and OTX1 expression was confined to anterior retina. Expression peaks for PAX6 occur at days 51–60 and for OTX2 occur around fetal days 48–54.We conclude that the human expression patterns correspond spatially with the patterns observed in the rat retina. Further, the expressions occur during similar fetal stages as described in the developing rat retina.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 27, Issue 5, August 2009, Pages 485–492
نویسندگان
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