کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2791788 | 1154974 | 2010 | 10 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Treatment of primary aldosteronism Treatment of primary aldosteronism](/preview/png/2791788.png)
The prevalence of primary hyperaldosteronism approaches 10% of all hypertensive patients, and besides efficient diagnostic procedures, effective treatment is of increasing importance to reverse increased morbidity and mortality. Aldosterone-producing adenoma and unilateral adrenal hyperplasia are amenable to cure by endoscopic adrenalectomy. Bilateral adrenal hyperplasia (micro- or macronodular), which comprises two-thirds of primary hyperaldosteronism, is treated primarily by mineralocorticoid receptor antagonists (starting dose 12.5–25 mg/day spironolactone with titration up to 100 mg/day, alternatively 50–100 mg/day eplerenone). If blood pressure is not normalised by this first-line treatment, additional treatment with potassium-sparing diuretics (amiloride or triamterene) or calcium channel antagonists is necessary. The start of medication should be closely monitored by serum electrolyte and creatinine controls.
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 24, Issue 6, December 2010, Pages 923–932