کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2792015 | 1154993 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular mechanisms for insulin resistance in treated HIV-infection
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کلمات کلیدی
Adipocytokines - آدیپوسیتوکین هاER stress - استرس استInsulin sensitivity - حساسیت به انسولینLipotoxicity - سمیت لیپتوIn vitro models - مدل های in vitroNucleoside reverse transcriptase inhibitors - مهار کننده های ترانس کپسول معکوس نوکلئوزیدHIV protease inhibitors - مهار کننده های پروتئینی HIVglucose transport - گلوکز حمل و نقل
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
علوم غدد
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Identification and characterization of the molecular mechanisms contributing to the high incidence of insulin resistance in HIV infected patients treated with combined antiretroviral therapy remains a critically important goal in the quest to improve the safety of antiretroviral treatment regimens. The use of in vitro model systems together with the investigation of drug-mediated effects on glucose homeostasis in animals and healthy human volunteers has provided important insight into the contribution of individual drugs to insulin resistance and affected cellular pathways. HIV protease inhibitor mediated blockade of glucose transport and nucleoside reverse transcriptase inhibitor mediated mitochondrial toxicity have been well characterized. Together with growing understanding of mediators of insulin resistance in non-HIV metabolic syndrome, additional cellular effects including the induction of endoplasmic reticulum and oxidative stress, altered adipocytokine secretion, and lipotoxicity have been integrated into this developing picture. Further elucidation of these mechanisms provides potential for the continued development of safer antiviral drugs and targeted treatment of insulin resistance in affected patients.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 25, Issue 3, June 2011, Pages 459-468
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 25, Issue 3, June 2011, Pages 459-468
نویسندگان
Paul W. MD, PhD,