کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2792191 1155008 2008 16 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Intracrine androgen metabolism in prostate cancer progression: mechanisms of castration resistance and therapeutic implications
چکیده انگلیسی

Residual tissue androgens are consistently detected within the prostate tumors of castrate individuals and are thought to play a critical role in facilitating the androgen receptor-mediated signaling pathways leading to disease progression. The source of residual tumor androgens is attributed in part to the uptake and conversion of circulating adrenal androgens. Whether the de novo biosynthesis of androgens from cholesterol or earlier precursors occurs within prostatic tumors is not known, but it has significant implications for treatment strategies targeting sources of androgens exogenous to the prostate versus ‘intracrine’ sources within the prostatic tumor. Moreover, increased expression of androgen-metabolizing genes within castration-resistant metastases suggests that up-regulated activity of endogenous steroidogenic pathways may contribute to the outgrowth of ‘castration-adapted’ tumors. These observations suggest that a multi-targeted treatment approach designed to simultaneously ablate testicular, adrenal and intracrine contributions to the tumor androgen signaling axis will be required to achieve optimal therapeutic efficacy.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Best Practice & Research Clinical Endocrinology & Metabolism - Volume 22, Issue 2, April 2008, Pages 243–258
نویسندگان
, ,