کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2792558 1155063 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism
ترجمه فارسی عنوان
دینامیت متیلاسیون هیستون و تنظیم ژن از طریق بررسی متابولیسم یک کربن اتفاق می افتد
کلمات کلیدی
متابولومیکس یک متابولیسم کربن، اپی ژنتیک زیست شناسی کروماتین
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
چکیده انگلیسی


• Histone methylation dynamics occur in response to changes in SAM and SAH
• Metabolism-regulated histone methylation affects gene expression
• Diet alters methionine metabolism and histone methylation in the liver
• Variation in human serum MET occurs at levels needed to alter histone methylation

SummaryS-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) link one-carbon metabolism to methylation status. However, it is unknown whether regulation of SAM and SAH by nutrient availability can be directly sensed to alter the kinetics of key histone methylation marks. We provide evidence that the status of methionine metabolism is sufficient to determine levels of histone methylation by modulating SAM and SAH. This dynamic interaction led to rapid changes in H3K4me3, altered gene transcription, provided feedback regulation to one-carbon metabolism, and could be fully recovered upon restoration of methionine. Modulation of methionine in diet led to changes in metabolism and histone methylation in the liver. In humans, methionine variability in fasting serum was commensurate with concentrations needed for these dynamics and could be partly explained by diet. Together these findings demonstrate that flux through methionine metabolism and the sensing of methionine availability may allow direct communication to the chromatin state in cells.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 22, Issue 5, 3 November 2015, Pages 861–873
نویسندگان
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